Olive oil has long been hailed as a golden elixir of health, praised by Mediterranean diets and wellness gurus alike. But a new study has stirred the pot — and your salad dressing — by revealing a surprising link between olive oil and weight gain. Published in Cell Reports, the research claims that oleic acid, the dominant monounsaturated fat in olive oil, could actually fuel the growth of fat cells — and potentially, your waistline.
Led by Michael Rudolph, assistant professor of biochemistry and physiology at the University of Oklahoma College of Medicine, the study dives into how different types of fats affect the body. And the findings are anything but bland.
Meet the ‘Fat Cell Soldiers’ That Olive Oil Might Be RecruitingIn a controlled study using mice, Rudolph and his team fed diets high in various fats — from coconut oil to soybean oil — to see how they impacted the body. But only one fat stood out: oleic acid. This compound, abundant in olive oil and processed foods, triggered an increase in the body’s “fat cell soldiers,” or precursor fat cells.
According to Rudolph, oleic acid stimulates a protein called AKT2 while suppressing another called LXR, both of which regulate fat storage. The result? More fat cells ready to store dietary nutrients — and a greater capacity for weight gain. “If the excess nutrients overtake the number of fat cells, obesity can occur,” Rudolph warned. “That can then lead to cardiovascular disease or diabetes if not controlled.”
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Olive oil may be slimming in moderation, but too much could expand your waistline. (Representational image: iStock)
Don’t Ditch Your Olive Oil Bottle Just YetBefore you throw your olive oil out with the bathwater, there’s a crucial caveat. The researchers stress that real-world diets are more complex — no one eats isolated fats in a lab setting. Plus, olive oil still boasts numerous health benefits: it’s rich in antioxidants, supports brain function, improves heart health, and has even been linked to reduced cancer and dementia risk.
The problem isn’t olive oil itself — it’s the quantity and context in which it’s consumed. Diets dominated by ultra-processed foods rich in oleic acid could tilt the balance. “Moderation is key,” Rudolph said. “Relatively balanced levels of oleic acid seem to be beneficial, but higher and prolonged levels may be detrimental.” Olive Oil is Still the Good Guy — Just Not the Only GuyIn a world obsessed with ‘superfoods,’ this study is a wake-up call that even healthy ingredients have their limits. Olive oil remains a nutritional powerhouse — but when consumed in excess or combined with unhealthy food habits, it might be helping your fat cells multiply behind the scenes. So, yes — drizzle that olive oil over your salad. Just don’t drown in it.