New York City’s famed Lipstick Building in Midtown has had its ups and downs over the decades — most notably as the headquarters of Ponzi king Bernie Madoff — but the revitalized tower’s dining scene is getting a fresh makeover.

Well-regarded Soho Italian restaurant MAMO will replace buttoned-down Wolfgang’s steakhouse at the iconic property, Realty Check has learned. The new restaurant on Lipstick’s East 53rd Street side is expected to open early next year, sources said.

“MAMO belongs at the center of where design and distinction matter most — nestled in one of Manhattan’s most architecturally bold addresses,” said CBRE’s Spencer Levy, who repped the tenant.

The Lipstick Building at 885 Third Ave. The revitalized tower’s dining scene is getting a fresh makeover. Lois Weiss

SL Green, which rescued the troubled, Philip Johnson- and John Burgee-designed tower at 885 Third Ave. five years ago, signed a 7,000 square-foot lease with the Italian Riviera-inspired eatery on West Broadway. MAMO’s uptown space includes 5,000 square feet on the ground floor and 2,000 square feet on the lower level.

MAMO’s Soho location will remain open.  Wolfgang’s was at the Lipstick building for 15 years.

“It was critical for the ownership to curate a tenant that not only activated the space, but enhanced the overall experience of the building,” said Newmark’s Adam Weinblatt, the Lipstick tower’s  retail leasing agent.

SL Green executive vice president Brett Herschenfeld said the new MAMO “will serve as an excellent amenity for both the building and neighborhood and speaks to the continued growth in the Third Avenue corridor, both for office leasing and now with many residential units coming.”

Among the latter are 680 apartments which SL Green is carving out at  its now empty office tower at 750 Third Ave. a few blocks south of Lipstick.

The MAMO deal marks the latest surprising twist at the 34-story Lipstick, which opened in 1986 as a prime symbol of the Postmodernist trend in architecture that also included Johnson and Burgee’s “Chippendale”-topped 550 Madison Ave., originally the headquarters of AT&T.

MAMO is expected to open early next year on Lipstick’s East 53rd Street side. Stephen Yang

SL Green, the city’s largest commercial landlord, took control of the Lipstick Building in 2020  after a previous owner defaulted on a mortgage.

The developer  bolstered the sagging Third Avenue scene, and electrified the investment-sale market, by selling about two-thirds of the 580,000 square-foot tower to Memorial Sloan-Kettering for $300 million three years ago.

The medical institution’s arrival marked a dramatic return to glory for the property, which had seen foreclosures, bankruptcy filings and a revolving door of previous owners.

SL Green, the city’s largest commercial landlord, took control of the Lipstick Building after a previous owner defaulted on a mortgage. William Farrington

Madoff added another layer of infamy, leasing three floors at the building for years before his scheme finally unraveled in 2008.

SL Green recently spent $16 million to renovate, redesign and brighten the lobby, which is home to a Daniel Boulud coffee bar. Major office tenants include EuroConsult, Inc., and law firm Reitler Kailas & Rosenblatt.

Previous owners of the Lipstick included Hines, the tower’s developer, as well as Tishman Speyer, Royal Canadian Bank, Marciano Investment Group and Ceruzzi Properties.

Dining and Cooking